Does your pet need a prescription for this medication?
Book a consultation now if you need to speak with a veterinarian
Apoquel Tablet for Dogs
Apoquel (oclacitinib) Tablets are a prescription Janus kinase (JAK) inhibitor from Zoetis that controls itch associated with allergic dermatitis and controls atopic dermatitis in dogs 12 months of age and older. Apoquel begins relieving allergic itch within 4 hours and effectively controls it within 24 hours, without being a steroid or an antihistamine. It is available in 3.6 mg, 5.4 mg, and 16 mg film-coated tablets.
Key facts
- Active ingredient: oclacitinib (as oclacitinib maleate), a selective JAK inhibitor
- Species: dogs 12 months of age and older
- Available strengths: 3.6 mg, 5.4 mg, and 16 mg tablets, from single tablets up to 100-count
- Form: film-coated oral tablet
- Typical use: itch from flea allergy, food allergy, contact allergy, and atopic dermatitis
- Manufacturer: Zoetis
How to use
Your dog's dose is determined by the prescribing veterinarian based on body weight. Per the label, Apoquel is typically given twice daily for up to 14 days, then once daily for maintenance, and may be given with or without food. Do not stop Apoquel abruptly without veterinary guidance, as allergic itch can return quickly.
Safety information
Apoquel is not for use in dogs under 12 months of age, dogs with serious infections, or breeding, pregnant, or lactating dogs. Because it modulates the immune system, it may increase susceptibility to infection (including demodicosis), and your veterinarian may recommend periodic bloodwork during long-term use. The most common side effects are vomiting, diarrhea, lethargy, and decreased appetite.
Frequently asked questions
How fast does Apoquel work?
Apoquel starts relieving itch within 4 hours and effectively controls allergic itch within 24 hours of the first dose.
Is Apoquel a steroid?
No. Apoquel is a Janus kinase (JAK) inhibitor that interrupts the itch and inflammation signaling pathways, so it works differently from corticosteroids and antihistamines.
What are the common side effects of Apoquel?
The most commonly reported side effects are vomiting, diarrhea, lethargy, and decreased appetite; contact your veterinarian if these persist.
Is a prescription required for Apoquel?
Yes. Apoquel requires a valid prescription from a veterinarian with a current relationship with your dog, typically an exam within the past 12 months.
Can cats take Apoquel?
No. Apoquel is approved for dogs only and is not approved for use in cats.
Where can I buy Apoquel tablets?
You can order genuine Zoetis Apoquel through our Vetcove pharmacy store; our pharmacy team verifies your prescription and ships it to your home.
Prefer a flavored option? See Apoquel Chewable Tablets for Dogs, or read our guide What you need to know about Apoquel.