A Veterinarian’s Guide to Azithromycin for Dogs & Cats
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Time to read 2 min
Clear, vet-approved info on uses, dosing, side effects, and safety
Azithromycin is a macrolide antibiotic that veterinarians sometimes prescribe extra-label to treat select bacterial (and occasionally certain parasitic) infections in dogs and cats. It isn’t FDA-approved for animals, so it should be used only under veterinary guidance. Always follow your vet’s directions and finish the full course unless instructed otherwise.
Fast tip: If your pet develops vomiting, diarrhea, or loses appetite, call your veterinarian for advice.
What Azithromycin May Treat
Your vet may choose azithromycin for specific respiratory, oral, skin, ocular, or GI-related bacterial infections, depending on your pet’s exam, diagnostics, and local resistance patterns. It doesn’t treat viruses (e.g., “colds”). Antibiotic and duration choices are individualized—your vet will set the plan.
The ranges below are typical educational ranges. Do not start/stop/change any medication without a veterinarian’s direction.
| Species | Typical Oral Dosing | Notes |
|---|---|---|
| Dogs | 5–10 mg/kg once daily or 10 mg/kg once on Day 1, then 5 mg/kg once daily |
Duration varies by condition; your veterinarian will advise. |
| Cats | 5–10 mg/kg once daily or 10 mg/kg once on Day 1, then 5 mg/kg once daily |
Duration varies by diagnosis and response to treatment. |
Missed dose? Give when remembered unless close to the next scheduled dose; if so, skip and resume. Do not double up.
How to Give It
With/without food: Either is okay; a small snack can reduce stomach upset.
Liquids: Shake well; measure with an oral syringe.
Tablets/Capsules: Offer a sip of water or a treat afterward to help swallowing.
Side Effects & Warnings
Common (usually mild): vomiting, diarrhea, decreased appetite.
Allergic reactions (urgent): hives, facial swelling, difficulty breathing— stop and contact your vet immediately.
Use with caution: pets with liver or heart disease.
Do not use in pets allergic to azithromycin/macrolides.
Small herbivores (rabbits/guinea pigs): highly sensitive—use only if an exotics vet directs.
Storage & Disposal
Store at room temperature in the original container, away from kids and animals.
Reconstituted liquid is typically discarded after 10 days (follow your label).
Use a drug take-back program when possible; otherwise mix leftovers with coffee grounds/kitty litter, seal, and trash. Do not flush.
How quickly does azithromycin start working?
Many pets begin to feel better within 1–2 days, but always complete the prescribed course unless your vet says otherwise.
Can I give azithromycin with food?
Yes—giving with a small meal or treat can help prevent stomach upset.
What if my pet vomits a dose?
If your pet vomits soon after a dose, call your vet before re-dosing. Persistent vomiting warrants an exam.
Can I use a leftover human Z-Pak?
No. Human prescriptions and dosing aren’t appropriate for pets. Only use medication prescribed for your pet by your veterinarian.
This article is not a substitute for an examination or individualized medical advice. Always follow your veterinarian’s directions.