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Denosyl from Nutramax Laboratories Veterinary Sciences is a SAMe-only liver health supplement for dogs and cats, providing S-adenosylmethionine in 90 mg, 225 mg, and 425 mg enteric-coated tablets. SAMe helps support glutathione production, the liver's most important antioxidant, and helps support liver cell repair and healthy bile flow.
Key facts
- Active ingredient: S-adenosylmethionine (SAMe): 90 mg, 225 mg, or 425 mg per enteric-coated tablet
- Species: Dogs and cats
- Available sizes: 30-count in 90 mg (cats & small dogs), 225 mg (medium dogs), and 425 mg (large dogs) strengths
- Form: Enteric-coated tablet; must be given whole
- Typical use cases: SAMe-only liver support when your veterinarian prefers a single-ingredient option, including support during long-term medication
- Brand: Nutramax Laboratories, the #1 veterinarian-recommended supplement company
How to use
Give on an empty stomach, at least one hour before feeding, for optimal absorption. Typical daily amounts: cats and dogs up to 12 lb, one 90 mg tablet; dogs 13-34 lb, one 225 mg tablet; dogs 35-65 lb, one 425 mg tablet; dogs 66-120 lb, two 425 mg tablets, or as directed by your veterinarian. Give tablets whole; do not split or crush. Follow with a small amount of water to help the tablet pass into the stomach.
Safety information
Denosyl has been shown to be well tolerated by dogs and cats with a wide margin of safety, and the manufacturer reports no known adverse interactions with medications or supplements. Store in a cool, dry place and keep out of the reach of children and animals. Ask your veterinarian before use in pets that are critically ill.
Frequently asked questions
What is the difference between Denosyl and Denamarin?
Denosyl contains SAMe only, while Denamarin combines SAMe with silybin from milk thistle for added liver support. Veterinarians may start with Denosyl when they want SAMe alone. Our guide, What You Need to Know About Denamarin, compares the two.
Can I give Denosyl with food?
No. Food substantially reduces SAMe absorption, so give Denosyl on an empty stomach at least one hour before a meal.
Can cats take Denosyl?
Yes. Cats typically receive the 90 mg tablet once daily, followed by a small amount of water.
How long does Denosyl take to work?
Response depends on the underlying condition; many veterinarians recheck liver values after several weeks of consistent daily use.
Where can I buy Denosyl?
Order through our Vetcove pharmacy store for authentic Nutramax product with autoship savings.
Looking for SAMe plus silybin in one tablet? See Denamarin Tablets.