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NexGard COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) from Boehringer Ingelheim is a once-monthly prescription spot-on that gives cats broad-spectrum parasite protection: fleas, ticks, heartworm disease prevention, roundworms, hookworms, and tapeworms in a single application. It is approved for cats and kittens 8 weeks of age and older weighing at least 1.8 lb.
Key facts
- Active ingredients: esafoxolaner (an isoxazoline), eprinomectin, and praziquantel
- Species: cats and kittens 8 weeks of age and older, weighing 1.8 lb or more — topical use only
- Protects against: fleas, ticks, heartworm disease (prevention), roundworms, hookworms, and tapeworms (Dipylidium caninum and Taenia taeniaeformis)
- Available sizes: Purple applicator for small cats 1.8–5.5 lb and Yellow applicator for large cats 5.6–16.5 lb, in 1, 3, 6, or 12-dose packs
- Form: monthly topical (spot-on) solution applied to the skin
How to use
Select the applicator size prescribed for your cat's weight and apply the entire contents topically, directly to the skin between the shoulder blades, once a month. For heartworm disease prevention, continue monthly applications for at least 3 months after your cat's last exposure to mosquitoes. Avoid direct contact with the application site until it is visibly dry.
Safety information
For topical use only in cats — do not administer orally. Esafoxolaner belongs to the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures; use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions are vomiting, application-site reactions, and reduced appetite; hypersalivation may occur if the product is licked or ingested. Talk with your veterinarian about risks versus benefits for your cat.
Frequently asked questions
Does NexGard COMBO kill ticks?
Yes. Esafoxolaner treats and controls tick infestations in cats, alongside its flea-killing activity, for a full month per application.
Does NexGard COMBO treat tapeworms?
Yes. The praziquantel component treats and controls tapeworm infections caused by Dipylidium caninum and Taenia taeniaeformis — coverage most feline flea-and-tick products don't include.
Is a prescription required for NexGard COMBO?
Yes. NexGard COMBO is a prescription medication, so your veterinarian must authorize it under a valid vet-client-patient relationship.
Can I use NexGard COMBO on my dog?
No. NexGard COMBO is labeled for cats only. For dogs, see NexGard Chew or NexGard PLUS.
Is NexGard COMBO safe for cats with a history of seizures?
Use with caution. Isoxazoline-class products have been associated with tremors, ataxia, and seizures. Discuss your cat's neurologic history with your veterinarian before starting.
Where can I buy NexGard COMBO?
Order it from our Vetcove pharmacy store — it ships from our home pharmacy and Autoship savings are available.
Looking for all-in-one parasite protection for the dogs in your household? See NexGard PLUS.